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1

Syntheses of 3',4'-dihydroxy-5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxy flavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase

Horie, Tokunaru, Tsukayama, Masao, Kourai, Hiroki, Yokoyama, Chieko, Furukawa, Masayuki, Yoshimoto, Tanihiro, Yamamoto, Shozo, Watanabe-Kohno, Shigekatsu, Ohata, Katsuya

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 915 KB

english, 1986

2

Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages

Toshiki Sakashita, Yoshitaka Takahashi, Takahiro Kinoshita, Tanihiro Yoshimoto

Journal:

Year:

1999

Language:

english

File:

PDF, 726 KB

english, 1999

3

Regulation of prostaglandin E2synthesis by cyclooxygenase induction in osteoblast MC3T3-E1

Shozo Yamamoto, Takeo Oshima, Tanihiro Yoshimoto, Chieko Yokoyama, Toshiyuki Takai, Tadashi Tanabe, Masayoshi Kumegawa

Journal:

Journal of Bone and Mineral Metabolism

Year:

1991

Language:

english

File:

PDF, 305 KB

english, 1991

4

Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia?

Hong Zhu, Tanihiro Yoshimoto, Shinobu Imajo-Ohmi, Maryia Dazortsava, Arumugam Mathivanan, Tetsumori Yamashima

Journal:

Journal of Neurochemistry

Year:

2012

Language:

english

File:

PDF, 938 KB

english, 2012

5

An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets

Yasushi Ozeki, Yoshie Nagamura, Hideki Ito, Fumiko Unemi, Yukio Kimura, Takehiro Igawa, Jun-ichi Kambayashi, Yoshitaka Takahashi, Tanihiro Yoshimoto

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 182 KB

english, 1999

6

Ultraviolet Ray Induces Chromosomal Giant DNA Fragmentation Followed by Internucleosomal DNA Fragmentation Associated with Apoptosis in Rat Glioma Cells

YOSHIRO HIGUCHI, YUJI MIZUKAMI, TANIHIRO YOSHIMOTO

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 2.41 MB

2003

7

Continuous antibody production by phytohemagglutinin-L-aggregated hybridoma cells

Hiroyuki Takamatsu, Hiroo Kawajiri, Yoshitaka Takahashi, Abdul Manaf Ali, Tanihiro Yoshimoto

Journal:

Journal of Immunological Methods

Year:

1999

Language:

english

File:

PDF, 166 KB

english, 1999

8

Arachidonate 12-lipoxygenases

Tanihiro Yoshimoto, Yoshitaka Takahashi

Journal:

Prostaglandins and Other Lipid Mediators

Year:

2002

Language:

english

File:

PDF, 164 KB

english, 2002

9

Growth stimulation and epidermal growth factor receptor induction in cyclooxygenase-overexpressing human colon carcinoma cells

Tanihiro Yoshimoto, Takahiro Kinoshita, Yoshitaka Takahashi, Toshiki Sakashita, Hiroyasu Inoue, Tadashi Tanabe

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 68 KB

english, 1999

10

Intracellular activation and induction of 12-lipoxygenase in mouse peritoneal macrophages

Hiroo Kawajiri, Isamu Makino, Tanihiro Yoshimoto

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 76 KB

english, 1999

11

Arachidonic acid induced c-fos mRNA expression in murine macrophages

Daming Zhuang, Hiroo Kawajiri, Tanihiro Yoshimoto

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 74 KB

english, 1999

12

Characterization of arachidonate 8-lipoxygenase expressed in COS-7 and Escherichia coli

Na Qiao, Yoshitaka Takahashi, Hiroyuki Takamatsu, Tanihiro Yoshimoto

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 74 KB

english, 1999

13

Cyclooxygenase 2 and prostaglandin E2 regulate the attachment of calcium oxalate crystals to renal epithelial cells

Katsuhito Miyazawa, Yoshitaka Takahashi, Nobuyo Morita, Manabu T Moriyama, Takeo Kosaka, Matomo Nishio, Tanihiro Yoshimoto, Koji Suzuki

Journal:

International Journal of Urology

Year:

2012

Language:

english

File:

PDF, 533 KB

english, 2012

14

Arachidonic Acid Converts the Glutathione Depletion-Induced Apoptosis to Necrosis by Promoting Lipid Peroxidation and Reducing Caspase-3 Activity in Rat Glioma Cells

Yoshihiro Higuchi, Tanihiro Yoshimoto

Journal:

Archives of Biochemistry and Biophysics

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

15

Diurnal Change of Arachidonate 12-Lipoxygenase in Rat Pineal Gland

Hiroo Kawajiri, Na Qiao, Da-Ming Zhuang, Tanihiro Yoshimoto, Hiroshi Hagiya, Shozo Yamamoto, Hiroyoshi Sei, Yusuke Morita

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 337 KB

english, 1997

16

Cyclooxygenase-2 Stimulates Production of Amyloid β-Peptide in Neuroblastoma × Glioma Hybrid NG108-15 Cells

Keiichi Kadoyama, Yoshitaka Takahashi, Haruhiro Higashida, Tadashi Tanabe, Tanihiro Yoshimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

17

Fatty acid cyclooxygenase activity stimulated by transforming growth factor-β in mouse osteoblastic cells (MC3T3-E1)

Koji Sumitani, Terushige Kawata, Tanihiro Yoshimoto, Shozo Yamamoto, Masayoshi Kumegawa

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 932 KB

english, 1989

18

Solubilization and partial purification of prostaglandin endoperoxide synthetase of rabbit kidney medulla

Santhoor G. Bhat, Yoshimoto Tanihiro, Yamamoto Shozo, Hayaishi Osamu

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1978

Language:

english

File:

PDF, 941 KB

english, 1978

19

2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis

Yoshimoto Tanihiro, Yokoyama Chieko, Ochi Kenkichi, Yamamoto Shozo, Maki Yoshitaka, Ashida Yasuko, Terao Shinji, Shiraishi Mitsuru

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1982

Language:

english

File:

PDF, 401 KB

english, 1982

20

Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid

Yoshimoto Tanihiro, Miyamoto Yoshiyuki, Ochi Kenkichi, Yamamoto Shozo

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1982

Language:

english

File:

PDF, 876 KB

english, 1982

21

Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung

Chieko Yokoyama, Keiko Mizuno, Hajime Mitachi, Tanihiro Yoshimoto, Shozo Yamamoto, Cecil R. Pace-Asciak

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1983

Language:

english

File:

PDF, 686 KB

english, 1983

22

Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells

Furukawa Masayuki, Yoshimoto Tanihiro, Ochi Kenkichi, Yamamoto Shozo

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1984

Language:

english

File:

PDF, 817 KB

english, 1984

23

Regional distribution of prostaglandin endoperoxide synthase studied by enzyme-linked immunoassay using monoclonal antibodies

Tanihiro Yoshimoto, Kiyohiko Magata, Hiroaki Ehara, Keiko Mizuno, Shozo Yamamoto

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1986

Language:

english

File:

PDF, 1.15 MB

english, 1986

24

Enzymological and immunological studies on a clinical case of platelet cyclooxygenase abnormality

Ehara Hiroaki, Yoshimoto Tanihiro, Yamamoto Shozo, Hattori Akira

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1988

Language:

english

File:

PDF, 911 KB

english, 1988

25

Analysis of non-heme iron in arachidonate 12-lipoxygenase of porcine leukocytes

Matsuda Satoshi, Suzuki Hiroshi, Yoshimoto Tanihiro, Yamamoto Shozo, Miyatake Akira

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1991

Language:

english

File:

PDF, 155 KB

english, 1991

26

Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation

Ishtiaq Mahmud, Toshiko Suzuki, Yasuchika Yamamoto, Hiroshi Suzuki, Yoshitaka Takahashi, Tanihiro Yoshimoto, Shozo Yamamoto

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1993

Language:

english

File:

PDF, 707 KB

english, 1993

27

Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase

Hiroshi Suzuki, Koji Kishimoto, Tanihiro Yoshimoto, Shozo Yamamoto, Fumihiko Kanai, Yousuke Ebina, Akira Miyatake, Tadashi Tanabe

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1994

Language:

english

File:

PDF, 1.58 MB

english, 1994

28

Arachidonate 12-lipoxygenase of rat pineal glands: Catalytic properties and primary structure deduced from its cDNA

Takahiko Hada, Hiroshi Hagiya, Hiroshi Suzuki, Toshiya Arakawa, Michihiro Nakamura, Satoshi Matsuda, Tanihiro Yoshimoto, Shozo Yamamoto, Takaharu Azekawa, Yusuke Morita, Kazunori Ishimura, Hee-yong Ki

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1994

Language:

english

File:

PDF, 1.58 MB

english, 1994

29

Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative

Koji Kishimoto, Michihiro Nakamura, Hiroshi Suzuki, Tanihiro Yoshimoto, Shozo Yamamoto, Toshifumi Takao, Yasutsugu Shimonishi, Ta-i Tanabe

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1996

Language:

english

File:

PDF, 686 KB

english, 1996

30

Arachidonic acid-induced chemiluminescence of human polymorphonuclear leukocytes

Sachiko Yoshimoto, Tanihiro Yoshimoto, Eiro Tsubura

Journal:

Biochemical and Biophysical Research Communications

Year:

1982

Language:

english

File:

PDF, 354 KB

english, 1982

31

Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase

Tanihiro Yoshimoto, Masayuki Furukawa, Shozo Yamamoto, Tokunaru Horie, Shigekatsu Watanabe-Kohno

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 432 KB

english, 1983

32

Molecular cloning and expression of human arachidonate 12-lipoxygenase

Tanihiro Yoshimoto, Yasuchika Yamamoto, Toshiya Arakawa, Hiroshi Suzuki, Shozo Yamamoto, Chieko Yokoyama, Tadashi Tanabe, Hiroyuki Toh

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 481 KB

english, 1990

33

Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)

Yoshitaka Takahashi, Natsuo Ueda, Tanihiro Yoshimoto, Shozo Yamamoto, Chieko Yokoyama, Atsuro Miyata, Tadashi Tanabe, Ichiro Fuse, Akira Hattori, Akira Shibata

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 453 KB

english, 1992

34

Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases

Juha Alanko, Yuko Kurahashi, Tanihiro Yoshimoto, Shozo Yamamoto, Kimiye Baba

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 226 KB

english, 1994

35

Reticulocyte lipoxygenase, ingensin, and ATP-dependent proteolysis

Shoichi Ishiura, Tanihiro Yoshimoto, Claude A. Villee

Journal:

Year:

1986

Language:

english

File:

PDF, 670 KB

english, 1986

36

ATP-dependent proteolysis, a fine system or a meaningless one? A reply

Shoichi Ishiura, Tanihiro Yoshimoto, Claude A. Villee

Journal:

Year:

1987

Language:

english

File:

PDF, 88 KB

english, 1987

37

Porcine leukocyte 5- and 12-lipoxygenases are iron enzymes

Peter M.H. Kroneck, Christophe Cucurou, Volker Ullrich, Natsuo Ueda, Hiroshi Suzuki, Tanihiro Yoshimoto, Satoshi Matsuda, Shozo Yamamoto

Journal:

Year:

1991

Language:

english

File:

PDF, 320 KB

english, 1991

38

Expression of human thromboxane synthase using a baculovirus system

Chieko Yokoyama, Atsuro Miyata, Kenji Suzuki, Yoshiki Nishikawa, Tanihiro Yoshimoto, Shozo Yamamoto, Rolf Nüsing, Volker Ullrich, Tadashi Tanabe

Journal:

Year:

1993

Language:

english

File:

PDF, 600 KB

english, 1993

39

The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NFκB/Rel

Toshiya Arakawa, Michihiro Nakamura, Tanihiro Yoshimoto, Shozo Yamamoto

Journal:

Year:

1995

Language:

english

File:

PDF, 680 KB

english, 1995

40

Arachidonate 12-lipoxygenase

Tanihiro Yoshimoto, Shozo Yamamoto

Journal:

Journal of Lipid Mediators and Cell Signalling

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

41

Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase

Yoshitaka Takahashi, Hong Zhu, Wanpeng Xu, Takashi Murakami, Tadao Iwasaki, Hiroaki Hattori, Tanihiro Yoshimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 224 KB

english, 2005

42

Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase

Hiroo Kawajiri, Yingshi Piao, Yoshitaka Takahashi, Takashi Murakami, Nobuyuki Hamanaka, Tanihiro Yoshimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 161 KB

english, 2005

43

Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12- lipoxygenase activation in glioma cells

Yoshihiro Higuchi, Hideji Tanii, Yoshiki Koriyama, Yuji Mizukami, Tanihiro Yoshimoto

Journal:

Year:

2007

Language:

english

File:

PDF, 365 KB

english, 2007

44

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Susumu Kotani, Eiko Sakaguchi, Shogo Warashina, Noriyuki Matsukawa, Yoshiyuki Ishikura, Yoshinobu Kiso, Manabu Sakakibara, Tanihiro Yoshimoto, Jianzhong Guo, Tetsumori Yamashima

Journal:

Neuroscience Research

Year:

2006

Language:

english

File:

PDF, 328 KB

english, 2006

45

Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells

Yi-Wen Liu, Ben-Kuen Chen, Ching-Jiunn Chen, Toshiya Arakawa, Tanihiro Yoshimoto, Shozo Yamamoto, Wen-Chang Chang

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1997

Language:

english

File:

PDF, 263 KB

english, 1997

46

Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2

Yoshitaka Takahashi, Futoshi Kawahara, Masakuni Noguchi, Koichi Miwa, Hiroshi Sato, Motoharu Seiki, Hiroyasu Inoue, Tadashi Tanabe, Tanihiro Yoshimoto

Journal:

Year:

1999

Language:

english

File:

PDF, 210 KB

english, 1999

47

Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non—insulin-dependent diabetes mellitus

Toshio Tohjima, Naoko Honda, Kentaro Mochizuki, Junichiro Kinoshita, Kenji Watanabe, Tomoyuki Arisaka, Ryuzo Kawamori, Michihiro Nakamura, Yuko Kurahashi, Tanihiro Yoshimoto, Shozo Yamamoto

Journal:

Year:

1998

Language:

english

File:

PDF, 700 KB

english, 1998

48

Molecular mechanism of low density lipoprotein oxidation by 12-lipoxygenase-overexpressing macrophages

Tanihiro Yoshimoto, Yoshitaka Takahashi, Wanpeng Xu, Takahiro Kinoshita, Toshiki Sakashita, Hiroshi Mabuchi

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 248 KB

english, 2002

49

12-Lipoxygenase increases neuronal excitability by inhibiting M-type potassium channels

Yoshitaka Takahashi, Tanihiro Yoshimoto, Naoto Hoshi, Haruhiro Higashida

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 69 KB

english, 2002

50

Overexpression of cyclooxygenase-2 stimulates amyloid β-peptide production in neuronal cells

Keiichi Kadoyama, Yoshitaka Takahashi, Haruhiro Higashida, Tadashi Tanabe, Tanihiro Yoshimoto

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

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